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The relationship between dose and cost is roughly linear for brand-name products: higher doses cost proportionally more due to the amount of active compound per injection pen
Cell-penetrating peptides represent another category of direct-acting therapeutic agents
For instance, with histidine, the neutral molecule exists between pH 6.00 and 9.17
Studies in Drosophila have characterized Porcupine and Wntless to be essential for these steps, and their deficiency leads to phenotypes similar to those of Wingless (homolog of Wnt) mutants (van den Heuvel et al., 1993
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