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Kyrtata, N., Emsley, H
when all GSH has been spent, NAPQI begins to bind to certain enzymes like N-10 formyltetrahydrofolate dehydrogenase and glutamate dehydrogenase, reducing their activity and killing the cells in the process
It also helps regulate homocysteine, an amino acid that, when elevated, is associated with cardiovascular and neurological risks
NAC heavily regulates Phase II (Conjugation), the essential follow-up process where these dangerous intermediate metabolites are bound to other molecules to make them water-soluble and safe for excretion via urine or bile
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