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Pharmacology 101: Activation of the GLP-1 receptor by GLP-1 RAs inhibits the release of the hormone motilin, which is important in stimulating gastric motility
Splitting into twice weekly injections has not been studied and may alter efficacy and side effect profiles unpredictably
The validity of random urine specimen albumin measurement as a screening test for diabetic nephropathy
Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025
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