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Clinical trials have demonstrated substantial reductions in hemoglobin A1c levels (often 1.5-2.5 percentage points, depending on dose) and significant weight loss (approximately 5-20% of baseline body weight, with higher percentages generally seen in non-diabetic populations with obesity)
Most of this can be explained by the link between weight and risk described in Part 1, but mortality improvements observed in clinical trials that cannot be predicted from weight-loss alone are also allowed for
It may generally be administered at any time of day, with or without food
The body has had time to adjust
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