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A 2013 study (PMID 23106397) employed DES(1-3) IGF-1 as an IGF1R-activating tool in oral squamous cell carcinoma cells to investigate resistance mechanisms to EGFR tyrosine kinase inhibitors
Based on the glutathione assay these drugs exhibit 140-to-6900-fold lower EC 50 values than WR-1065, some in the nanomolar range
Hochstrasser, H
As shown in Figure 5M, mechanistic studies demonstrated that the electrical stimulation generated by the piezoelectric membrane exerts therapeutic effects by activating the PI3K/AKT signaling pathway: the electric field promotes PI3K-catalyzed generation of PIP 3 , which subsequently activates AKT serine/threonine kinase, triggering a cascade of intracellular events that regulate critical biological processes, including cell survival, proliferation, and migration
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