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Darzalex (daratumumab) and Darzalex Faspro (daratumumab and hyaluronidase-fihj) Disease area(s): Oncology/hematology Manufacturer(s): Johnson & Johnson 2024 Sales (USD): $11.67 billion Why it sold so well: Anti-CD38 monoclonal antibody Darzalex and its subcutaneous formulation, Darzalex Faspro, had exceptional success in 2024, becoming J&Js top-selling pharmaceutical product with global net sales of $11.67 billion a 19.8% increase over 2023