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The BBB prevents almost 98% of small molecule drugs and almost all large molecule therapeutics from entering the brain
If this translates clinically, it could explain signals across alcohol, nicotine, opioids, and other substances
Titrate: Step up to 500 mcg total around week 5
The CMA adds that patients who choose to stay on the brand-name drug will typically be asked by their plan to pay the price difference out of pocket
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