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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

Hollow microneedles deliver serum through the channel during the act of channel creation itself , which is the only point at which the dermal layer is actually accessible to a topical molecule the size of a peptide

Many compounds exist as hydrates unless they're treated very carefully