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August 13, 2025

10.1016/j.anireprosci.2016.03.024 62

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Multiple fibroblast culture studies have demonstrated that GHK Cu stimulates expression of: Collagen type I the primary structural collagen of skin, tendon, and bone Collagen type III key in early wound healing and elastic connective tissue Elastin the protein responsible for skin elasticity and recoil Dermatan sulfate and chondroitin sulfate glycosaminoglycans that maintain skin hydration and structural integrity Hyaluronic acid a major skin hydration molecule A key study by Maquart et al