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Semaglutide is a GLP-1 receptor agonist, not insulin

Comparative studies show similar metabolic adaptations whether weight loss occurs through GLP-1 medications or through diet and exercise alone

The authors hypothesize that this paradoxical worsening is due to a cytokine imbalance, similar to what is seen with the exacerbation of disease after administration of biological treatments like anti-TNF, which increases interferon (IFN)- release and leukocyte chemotaxis [25]