It was initially planned to recruit 20 analyzable patients (who completed the two-treatment periods) to have 80% power to detect, with a two-sided test at 0.05 significance level, an absolute decrease in percentage over total target of 10% under the A-dopamine period compared with the control (oral l-dopa-alone treatment) period, by assuming a standard deviation of 15% and a within-patient correlation of 0.5 to account for the crossover design
Source: Prkacin et al., 2001 Multi-Organ Protection: Brain, Liver, Kidney, Lung The most comprehensive study came from Gojkovic et al
GHK-Cu binds to cell surface receptors and activates a cascade of regenerative processes collagen and elastin synthesis, antioxidant enzyme activity, and tissue remodeling that mirror the body's own wound-healing response
Future work should focus on 3D cultures and in vivo animal models that more accurately mimic a natural cellular environment, allowing a true evaluation of the peptides effectiveness as an anti-aging compound