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Since GHK-Cu levels decline naturally with age, ongoing supplementation helps maintain the gains achieved during intensive treatment phases

In addition, increased foreign viral antigens from EBV reservoirs, SARS-CoV-2 or vaccine viral vectors, in individuals carrying ancestral HLA class II alleles with the ability to detect a greater number of antigens and activate a greater number of T and B cells, could increase the activation of autoreactive T cells due to their promiscuity and molecular mimicry of self-antigens with viral antigens (112)

Therefore, 23 clinical studies published from 2020 to 2025 are presented from various countries that examined oral collagen supplementation in women who were aged 30 to over 65 years (Table 1)

For collagen-specific support, GHK-Cu can be added at systemic doses via subcutaneous administration or applied topically over affected areas