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Because these mutations are typically compound heterozygous and result in partial rather than complete loss of SECISBP2 function, they produce a distinctive clinical syndrome rather than embryonic lethality (which is observed in Secisbp2 -null mice [110])
doi: 10.1074/jbc.M110.118620
In women, the X chromosome is randomly inactivated, leading to a transcriptionally silenced chromosome, resulting in mosaic pattern expression by cells
That thermal energy causes micro-damage to your sweat glands, temporarily inactivating them
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