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For context, tirzepatide 15 mg in the SURMOUNT trials had discontinuation rates around 6-7%
The SURMOUNT-1 trial specifically noted that GI adverse events were the most common reason for treatment discontinuation at higher doses
In line with this possibility, conditions that result in increased cholesterol accumulation in lysosomes such as the use of tricyclic antidepressants can potentiate APAP hepatotoxicity
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