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The SURMOUNT-1 trial (Jastreboff et al., NEJM 2022) is the landmark efficacy data: tirzepatide at 15mg weekly produced 22.5% average body weight reduction over 72 weeks in adults with obesity without diabetes the highest weight reduction ever documented in a pharmaceutical trial
Abbreviations GLP-1RA: Glucagon-Like Peptide-1 Receptor Agonists SGLT2: Sodiumglucose cotransporter 2 DPP4: Dipeptidyl Peptidase-4 T2D: Type 2 diabetes AF/Aflutter: Atrial fibrillation or flutter TSH: Thyroid-stimulating hormone MPR: Medication possession ratio PS: Propensity score IPCW: Inverse probability censoring weight SMD: Standardized mean differences References McCoy RG, Herrin J, Swarna KS, Deng Y, Kent DM, Ross JS, et al
How NAC Works in the Brain (in Simple Terms) Researchers believe NAC helps in three major ways: Boosts Brain Protection: NAC increases glutathione, an antioxidant that protects brain cells from stress and damage[1]
Dose Increases Each dose escalation triggers a new adjustment phase
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