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FerroLOXIN-1 and FerroLOXIN-2, developed by Dar et al., inhibit lipid peroxidation and ferroptosis both in vitro and in vivo by specifically targeting the 15LOX-2/PEBP1 complex, which has become a critical target in ferroptosis research (Dar et al., 2023)
Moreover, LDL-C, triglycerides, ApoB, and Lp(a) all decreased significantly, highlighting cardiometabolic benefits of the compound
[16] After this initial phase, the frequency is reduced
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