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In brief, mouse electrocardiography was measured in females [Young ( n = 6), Old Con ( n = 8), and Old mAb ( n = 7)] and males [Young ( n = 5), Old Con ( n = 6), and Old mAb ( n = 5)], using a Visual Sonic Vevo2100 imaging system (FUJIFILM VisualSonics Inc, Toronto, ON)
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General categories of these cytotoxic payloads include anti-microtubule agents (i.e., DM1) and agents that exert DNA damage such as topoisomerase I inhibitors (i.e., SN-38, deruxtecan) [16]
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