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The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)
2.2 Preparation of crude purified hemoglobin For purified hemoglobin preparation, pRBCs tube was placed in a dry-ice acetone bath for few seconds until the PRBCs freeze and visibly seen as solid
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