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Gradual taper of dose The Approach For patients who want to find the lowest effective dose or to discontinue completely, a gradual taper means stepping the GLP-1 dose down in small, planned increments (typically using the same titration steps as initiation, but in reverse) to test whether benefit can be maintained with less medication or none at all

An update on the effect of incretin-based therapies on -cell function and mass

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360eee-1] if the conditions in section 503B of the FDCA are met