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New data from a massive cohort study of 2 million patients published in Nature Medicine in January 2025, suggest that GLP-1 medications may actually reduce the risk of substance use disorders , including Cannabis Use Disorder (CUD)

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Participants had moderate to severe fibrosis (F2-F3), not cirrhosis (F4) A separate trial in patients with cirrhosis showed semaglutide didnt significantly improve fibrosis in that population Maintaining improvements likely requires ongoing weight management For fibrosis, about 37% of participants showed improvement of at least one stage

These findings suggest that CPT1C is a regulator of FA homeostasis in cancer cells and might be indirectly involved in the modulation of CPT1A activity through the lowering of cellular malonyl-CoA levels