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Big picture view: Known as GLP-1 receptor agonists, the drugs have soared in popularity in recent years
Owing to these nutraceutical properties, a growing number of human clinical studies have investigated the efficacy, safety, and bioavailability of shiitake-derived products
Current evidence is derived primarily from preclinical studies and a limited number of clinical trials, which may not fully represent the diverse HFpEF population
Timing can vary depending on the severity of symptoms, the underlying cause, diet, medications, stress levels, and whether the gut issue is inflammatory, infectious, structural, or functional
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