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The Specialist Pharmacy Service (SPS) and NHS practice guidance advise that when a GLP-1 receptor agonist is introduced, any DPP-4 inhibitor should generally be discontinued due to the mechanistic overlap and lack of additive benefit
Q: Is Retatrutide approved and available now
Yes, very commonly
Because rodents have a higher density of GLP-1 receptors in thyroid C-cells, regulators issued boxed warnings about potential medullary thyroid carcinoma risk
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