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In 2015, 32 white rabbits were divided into four groups of eight, and each group was given a placebo, AOD 9604, hyaluronic acid, or a combination of AOD 9604 and hyaluronic acid for 4 to 7 weeks
The peptide triggers downstream signalling cascades (angiogenesis via VEGFR2, fibroblast migration via FAK-paxillin, nitric oxide system engagement) whose biological effects persist for days to weeks after the peptide itself has been cleared
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