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SR18 exhibited an average hydrodynamic diameter of 4.001 nm with a polydispersity index (PDI) of 0.2289, indicating a relatively uniform and predominantly monomeric population in 1 X PBS, compared to 10 M BSA (hydrodynamic diameter 7.631 nm and PDI 0.1645) as shown in Supplementary Figure S5
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Through dual GLP-1 and GIP receptor activation, tirzepatide targets metabolic dysfunction while influencing anatomical and inflammatory factors associated with upper airway collapse (17, 18)
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