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Under the hypoxic stress, cancer cells activate the phosphorylation of p53 in the serine 15 region, thereby inhibiting the formation of p53RPA70 complex [104]
8,9 This drug-induced depletion may be particularly serious in the elderly, who already suffer from a natural age-related CoQ10 deficiency
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Exercising is another
Insulin has important effects not only on glucose uptake but also on protein turnover in skeletal muscle, reducing muscle protein breakdown and (in some studies where sufficient amino acids are present) increasing muscle protein synthesis [45]
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