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Conclusion: The LT administration of low dose Phenobarbital in combination with CCl 4 intoxication and WD represents a novel rat model with accelerated development of advanced liver fibrosis mimicking all key characteristics of decompensated NASH-cirrhosis in humans

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Biotechnology Journal

While these effects initially made GLP-1 seem a promising candidate for drug development, the earliest clinical studies from 1992 and 1993 revealed that GLP-1s half-life in the body was disappointingly short