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This points to the hypothesis that chronic hyperglycemia in diabetes, along with dysregulated central sensing of glucose concentrations in diabetics, may impair central transport of GLP-1 receptor agonist and explain the reduced efficacy for weight loss in type two diabetic patients. Geisler also discussed astrocytes
In the SURMOUNT-1 trial, tirzepatide treatment resulted in favorable changes in body composition, with fat mass reduction approximately threefold greater than lean mass reduction
Presented for research literature review only Ponomareva EV (2017)
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