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By promoting the development of new capillaries in injured areas, these peptides ensure that healing cells receive the oxygen and nutrients they need to repair tissue effectively

Achieving sufficient and sustained drug concentrations specifically at the site of myocardial injury remains a major obstacle for systemically administered agents due to poor pharmacokinetics, rapid clearance, and lack of specific targeting to affected cells ( Significant patient heterogeneity in baseline oxidative stress levels, comorbidities, and genetic predispositions further complicates a one-size-fits-all approach, influencing individual responses to targeted therapies (Zou et al., 2024)

Dec 1992;6(4):209-21

2.4.1 Inflammation Oxidative stress is a potent trigger and amplifier of the inflammatory response in the ischemic and reperfused myocardium