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Fish Shellfish Immunol 127:228237
Can a labial melanotic macule turn into melanoma
As in the LEAN study, the primary outcome is histologic resolution of NASH without worsening of fibrosis after 72 weeks of treatment, while secondary outcomes include improvement in liver fibrosis (1 stage) with no worsening of NASH, NAFLD activity score, as well as multiple serum markers of fibrosis
Patients with preexisting retinopathy appear particularly vulnerable to this early worsening effect, especially those with severe nonproliferative or proliferative disease
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