The major category factors include medications, diet, inflammation, autoimmune conditions, gut health, and genetics: Non-steroidal anti-inflammatory drugs (NSAIDs): Aspirin, ibuprofen, and other NSAIDs can interfere with DAO function
Aligned with these national priorities and the 2025 weight management campaign, the approval of mazdutide represents a timely and important milestone
Stahl quote: "Follow the FDA label and never get anybody better" [22:10] When GLP-1s aren't appropriate [24:01] Case study: patient on paliperidone gaining weight despite tirzepatide [25:52] Discovery of nucleus tractus solitaris [28:26] The "are we allowed to prescribe this?" debate [29:10] Valproic acid, propranolol, and scope of practice [30:01] Bipolar disorder, obesity, and mood episode frequency [30:49] Moving beyond the monoamine hypothesis [31:19] UK paper: no proof depression is serotonin deficiency [33:23] Alternative treatments: TMS, ketamine, GLP-1s [34:03] Dr
Side effects: Gastrointestinal issues like oily stools and flatulence may occur