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Artesunate is a clinically well-tolerated compound that acts synergistically with sorafenib to induce ferroptosis in the HCC cell lines Huh7, SNU-449, and SNU-182 (97)
In melanoma patients refractory to antiPD-1 therapy, the combination of Talimogene laherparepvec (T-VEC), an oncolytic herpesvirus, with pembrolizumab (NCT04068181) showed enhanced systemic immune activation and tumor response
Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels
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