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In the SUSTAIN 6 trial, over 3,297 patients with type 2 diabetes with established chronic kidney disease and/or cardiovascular disease underwent randomization to semaglutide or placebo and were followed for 2 years resulting in a 26% risk reduction in the combined endpoint of rate of cardiovascular disease, nonfatal myocardial infarction, or nonfatal stroke [47]
This side effect is usually mild and resolves after stopping the medication
However, rapid destruction of bacteria can cause an influx of endotoxins resulting in greater toxicity
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