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Abbreviations RM: Rasagiline mesylate PLGA: Poly (D, L-lactide-co-glycolide) SEM: Scanning Electron Microscopy PD: Parkinsons disease MAO-B: Monoamine oxidase-B PVA: Polyvinyl alcohol DSC: Differential Scanning Calorimetry FFD: Fractional Factorial Design CCD: Central Composite Design FAD: Flavin Adenine dinucleotide CMS: Critical Material Attributes CPP: Critical Process Parameters API: Active Pharmaceutical Ingredient ATR-FTIR: Attenuated Total Reflectance Fourier-transformed infrared spectroscopy LPS: Lipopolysaccharide PDI: Polydispersity Index References Kouli A

In GHRH neurons, there is an estrogen receptor ER whose deletion in mice delays female puberty, since in females a group of GHRH neurons changes their phenotype to start producing Kiss1 (a key peptide in gonadotropic regulation)

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