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Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4

10.24966/PMRR-0177/100002 Pulmonary Med Respir Res

To make sure this medicine is safe for you, tell your doctor if you: have a stomach or intestinal disorder have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems with digesting food have or have had pancreas problems (pancreatitis) are planning surgery or other procedure that requires anesthesia or deep sedation have kidney disease have eye problems caused by diabetes (retinopathy) are pregnant or intending to become pregnant are breastfeeding or intending to breastfeed

Muscle loss is a significant concern, given tirzepatide's better lean mass preservation data