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Whilst GLP-1 therapies improve insulin sensitivity, promote weight loss, and reduce visceral fatfactors that can influence the hypothalamic-pituitary-adrenal axisthey are not licensed or recommended for treating hypercortisolism
We know men lose less weight than women, and paradoxically, people with diabetes also lose less weight
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Further, the suppression of ARC AgRP/NPY neurons by intragastric lipids is blocked by a CCK receptor antagonist [148] and is mediated by vagal afferents, while that of glucose is mediated by spinal afferents [150]
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