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Gene-expression changes in dermal fibroblast cultures collagen, decorin, matrix-metalloproteinase regulation

However, appropriate surgical planning requires a deeper understanding of how GLP-1 RAs-induced rapid weight loss affects collagen and elastin synthesis, the extracellular matrix, and wound healing dynamics

Better understanding of GLP-1s mechanism of action and how to best sustain weight loss are matters of intense investigation

For example, studies using radiolabeled exenatide have shown that it can readily enter the mouse brain, though this central uptake appears to diminish at higher doses (Kastin and Akerstrom, 2003)