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An independent replication with nuance More recently, an independent study published in Biogerontology in 2025 reported that Epitalon increased telomere length in human cell lines, and importantly dissected the mechanism by cell type: in normal cells (fibroblasts and mammary epithelial cells) it appeared to act through canonical hTERT/telomerase upregulation, whereas in certain breast-cancer cell lines it appeared to lengthen telomeres via the alternative lengthening of telomeres (ALT) pathway rather than through a genuine rise in telomerase enzyme activity
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Right panel, Quantification of p27 IHC staining in SK-MEL103 tumours
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