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(2015) Advances and challenges of liposome assisted drug delivery
Despite their shared mechanism of action, GLP-1RAs differ pharmacologically in terms of their molecular structures (e.g., lipidation or adding lactam bridges), pharmacokinetics (e.g
Modelling The sequence corrected model of exendinP5-GLP-1R-Gs (PDB: 6B3J) 13 was used as the initial template and fit in the cryo-EM density maps in UCSF Chimera (v1.14) for both the exendin-4 and oxyntomodulin bound structures, followed by molecular dynamics flexible fitting (MDFF) simulation with nanoscale molecular dynamics (NAMD) 53
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