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359,360 Functional abnormalities also play a critical role in DPN, including altered thalamic activity and disrupted thalamocortical connectivity
G.ZhaoN.WangZ
Different strategies influence pro-inflammatory (M1) or anti-inflammatory/reparative (M2) macrophage phenotypes by modulating key metabolic enzymes, nutrient-sensing signals, or metabolite levels, and have shown certain therapeutic potential in a variety of inflammatory or autoimmune disease models
The most notable of these potential complications would be insulin resistance and severe cardiovascular complications [R, R]
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