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This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

The choice of ester matters less than consistent administration

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Semaglutide weight loss injections are provided as a standalone treatment, but patients can always combine them with lifestyle changes