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Phase I and II clinical trials conducted have shown improved cognitive and motor function with different drugs from GLP-1RA group although the small sized and limited duration of trials have not provided a conclusive result to influence the practice, although with further advancement in ongoing trials effects observed may be noteworthy for intervention in future practice (119)

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Three different mechanisms of GST-catalyzed isomerization are known: (i) carbon-carbon double bond shifts, (ii) intramolecular redox reactions and (iii) cis-trans isomerizations 21

The receptor-pharmacology layer is the smallest and the most transferable