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(4) Compared with spontaneously formed cancer tissues in humans, cancer tissues in animal models lack the ability to reproduce the characteristics of human malignant tumors, which may lead to differences between the therapeutic effects observed in preclinical studies and clinical efficacy
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In addition to having to overcome the IGF-1/IGFBP complex issues, the IGF-1 analytical techniques have recently had to contend with the existence of therapeutic forms of IGF-1
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: Wiseman LR, Brogden RN
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