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BRAF V600E mutations identify a unique subtype of metastatic non-small cell lung cancer that presents an actionable biomarker that precision medicines like [the Braftovi/ Mektovi] combination therapy can help address, said Gregory Riely, vice chair of clinical research in the Department of Medicine at Memorial Sloan Kettering Cancer Center and a PHAROS investigator, in a prepared statement

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Because of the hypothesised abnormalities in oxidative stress and suggested links between initial inflammation, glutamate excitotoxicity and neuronal dysfunction/loss [25], our additional interest was in, GSH, glutamate and glutamine, and total choline as biomarkers of these processes