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Potential side effects leading to dose reductions before maximum effects seen
NHS costs differ due to procurement arrangements and are not equivalent to private list prices
They ran large-scale clinical trials, navigated regulatory hurdles, and scaled up manufacturing
JAMA Network Open, 2022 This retrospective study notes that patients who remained on lower doses of semaglutide experienced fewer side effectssuggesting that gradual titration and submaximal dosing may enhance tolerability without compromising outcomes
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