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Know when to ask for help If constipation becomes persistent, painful, or severe, it is important to speak with your healthcare provider
Some are exaggerated
Advanced tools, including in vivo autophagy/mitophagy reporters, high-resolution mitochondrial imaging, and integrative multi-omics, are needed to resolve these discrepancies and identify key downstream mediators such as NLRP3, the Nur77-IDH1 axis, and regulators of ferroptosis and pyroptosis
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