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10.4103/1673-5374.380869 488 XiongR.GunterC.FlemingE.VernonS

1810): glucagon receptors also couple to Gi protein in human atrial myocytes, and Gi upregulation in the cardiomyocyte inhibits cAMP formation and Gs-coupled signal transduction, so glucagon action in the chronically failing heart "may theoretically be impaired." Two limits on how far that carries: the condition Petersen describes is heart failure , not obesity or sedentary metabolic dysfunction, and the impairment is offered as a hypothesis, not an observation

The contrast with oral semaglutide's food effect is stark