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Weight Loss : Weight loss or vigorous exercise can lead to menstrual irregularities in women
"So it could potentially be really, really appealing for the treatment of MASH [a chronic liver disease], for example." While it's still uncertain whether final retatrutide trial results will be available to submit to the FDA in 2025, Jonsson said it "might" happen, setting up the drug to potentially become available in 2026
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It seems that weight loss will likely be very important for the benefits of the GLP-1 medicines in some conditions, and much less important, or not at all essential, for benefits in other disorders. According to Lane, although GLP-1 receptor agonists show promise in reducing cardiovascular risk factors, long-term cardiovascular safety trials are needed to assess cardiovascular mortality and events
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