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Participants taking liraglutide also achieved a 5.5% total body weight change compared with placebo over the 48-week study period

We need more research, more focus on hormonal mechanisms, andabove alla real inclusion of sex as a biological variable in future clinical trials

Supplementary table S3 compares the characteristics of the target trials and the emulated trials using our observational datasets

Some protocols utilize twice-daily dosing (morning and early afternoon) to maintain more stable effects throughout the day, though once-daily administration appears sufficient for most users based on the sustained metabolic effects of the peptide