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Because it engages all three, retatrutide is often described as a triple agonist. For comparison, tirzepatide is a dual agonist (GLP-1 and GIP) and semaglutide is a single agonist (GLP-1)

As your body works to process the meal alongside the medication, your metabolism increases, which can lead to temporary heat and perspiration.

This is particularly important for individuals using Ozempic to manage type 2 diabetes