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Mechanisms of action Preclinical studies document: Anxiolytic effect without sedation in classical tests (elevated plus maze, open field, light-dark box) GABAergic system modulation : allosteric potentiation of GABA-A observed ex vivo Enkephalin increase (endogenous opioid peptide) and serotonergic modulation Immunomodulatory effects inherited from tuftsin: macrophage activation, T-helper modulation Behavioural models Anxiolysis is measured via time spent in open arms of the elevated plus maze (EPM), visit ratio of central zones of open field , and exit latency in light-dark box

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It is not clear whether the observed content is due to import from the medium or synthesis per se is carried out by the strains

Particulirement prsent dans les cellules hpatiques, le glutathion prsente galement la capacit de lier, au sein de complexes stables, certaines mtaux et autres xnobiotiques